Tutorials

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Contents

Why Have an Immune System?

Infectious Disease

• Introduction to the Pathogens
• Normal Flora
• Infection and Pathogenesis
• Disease Spread
• Disease Diagnosis and Treatment

Immunity Rules: Overview of the Immune System

• Immunity Protects Us from Infectious Disease
• The Immune System: Cells and Organs
• Immunology Rules!
• Seeing and Eliminating Antigen

Antigen

• Foreign (Pathogen) Antigens
• CD Antigen Markers

Cytokines

• Properties of Cytokines
• Cytokine Activities
• Cytokine Receptors

• Complement Functions
• Complement Cascades
• Regulation of Complement Function

Innate Immunity : Off-the-Shelf Responses to Pathogens

• Infection and Immunity Part 1
• Migration and Adhesion
• Pathogen Elimination

How Does the Adaptive Immune System Recognize Danger?

Antibody

• Molecular Structure
• Biological Functions

Antibody Genes

• Naming and Organization
• Somatic Recombination
• Somatic Hypermutation and Isotype Switching

TCR

• T Cell [antigen] Receptor
• TCR Somatic Recombination

MHC: Antigen Processing and Presentation

• MHC Structure and Function
• Antigen Processing and Presentation
• MHC Gene Expression

Receptor Signaling

• Ligand-Receptor Binding Alters Cell Function
• Antigen Receptor Structure and Signaling
• Other Receptor Pathways

B Cell Development

• Generation of B Cells
• Regulation of B Cell Development
• Positive Selection of B Cells
• Negative Selection of B Cells
• B Cell Heterogeneity

T Cell Development

• Generation of T Cells
• Positive Selection of T cells
• Negative Selection of T Cells
• gd T Cells

How Does the Adaptive Immune System Eliminate Pathogens?

T Cell-Mediated Immunity

• T Cell Activation
• Properties of Effector Cells
• Cytotoxic T Cells
• Macrophage Activation by Th1 (Inflammatory T) Cells

Humoral Immunity

• Antibody Production
• Isotype Distribution and Function
• FcR⁺ Accessory Cells

The Big Picture: Immunity to Infection

• Infection and Immunity Part 2
• Adaptive Immunity to Infection
• Mucosal Immunology
• Immune Memory
• Regulation of Immune Responses

What Happens When Things Go Wrong?

Microbe Evasion of Immune Responses

• Microbe Evasion of Immune Responses
• HIV and AIDS

Inherited Immune Deficiencies

Too Much of a Good Thing: Allergy and Hypersensitivity

• IgE Synthesis
• Effector Mechanisms of Allergy
• Hypersensitivity Disease

Autoimmunity

• Autoimmunity
• Tolerance

Manipulating the Immune System

Transplantation

• Transplantation
• Clinical Immunosuppression

Tumor Immunology

Vaccines

• Rationale for Vaccine Development
• Vaccine Types
• Experimental Approaches to Vaccine Development

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http://microvet.arizona.edu/Courses/MIC419/tutorials.html
Written by Janet M. Decker, PhD      jdecker@u.arizona.edu
Last modified February 5, 2004