Home -- Symptoms -- Cycles -- Mechanisms of Inflammation: Immune Response

Mechanisms of Inflammation: Immune Response

A Medline Search.

Date: February 3, 1999


A role for IL-1 in the pathogenesis of Lyme disease.
Beck, Habicht, Benach et al. (Stony Brook)
Cytokines and the pathogenesis of neuroborreliosis: Bb induces glioma cells to secrete IL-6. Habicht, Katona, Benach (Stony Brook)
Bb induced TNF-alpha:
  • elevated levels of TNF-alpha in patients' sera and synovial fluids,
  • TNF-alpha produced from human periph. blood monon. or mouse periton. cells within 24 h in a (Bb) dose-dependent manner (max. at 1 ... 10 Bb per mononuclear cell).
Defosse, Johnson (Minneapolis) 1992
B cells may amplify T cell responses by recruiting T cells to regions with minute amounts of Bb antigens. Goronzy, Hanson, Weyand (Rochester) 1992
Bb Osp A and Osp B possess B-cell mitogenic and cytokine-stimulatory properties:
  • B cell (but not T cell) proliferation.
  • induction of IgM. Il-6 & TNF-alpha from macroph., HEC, HMC.
Threshold: cOsp > 10 ng/ml.
Tai, Ma, Weis (Salt Lake City)
Bb increases IL-6 production by fibroblasts. Jones, Germain, Riley et al. (Tampa) 1994
Bb OspA induces nuclear translocation of NF-kappa B and inflammatory activation in HEC.
Wooten, Modur, McIntyre, Weis (Salt Lake City) 1996
Bb Osp (lipoprotein) activate vascular endothelium in vitro.
Sellati, Abrescia, Radolf, Furie (Stony Brook)
Induction of IL-6 by Bb in different cell cultures. Ponte et al. (Madrid) 1997
Induction of IL-6 by lipoprotein that is released by growing bacteria. Zhang et al. (Galveston) 1997
Levels of endogenous IL-1, IL-6, and TNF- alpha in congenic mice infected with Borrelia garinii.
Isogai, Kimura, Hayashi et al. (Hokkaido)
Humoral immunity apparently plays the greatest role in clearance of the organism.
Hu, Klempner (Boston)
Bb induced production of IL-8 by cultured EC occurs independently of secreted IL-1 and TNF-alpha and is required for transendothelial migration of neutrophils (Bb). Burns, Sellati, Teng, Furie (Stony Brook) 1997
Osp induced production of IL-1b, IL-6 and TNF-alpha in a concentration-dependent manner with peak levels at 12-24 h. Häupl et al. (Berlin) 1997
Bb/Osp induced production of IL-1, IL-8, TNF in synovial explant cultures within hours after challenged by untreated, sonicated or 16 h UV-irradiated Bb. Straubinger, Summers, Erb et al. (Cornell) 1998
Bb induced production of IL-10 in human periph. blood monon. cells Giambartolomei et al. (Covington, LA) 1998
Although much progress has been made in the characterization of the organism, spirochetal factors responsible for infectivity, immune evasion, and disease pathogenesis remain largely obscure. Hanson et al. (Gaithersburg, MD) 1998
Bb = Borrelia burgdorferi.
EC = endothelial cell.
HEC = human endothelial cells.
HMC = human mononuclear cells.
HPBMC = human peripheral blood mononuclear cells.
Osp = outer surface (lipo-)proteins of Bb.
UV = ultra-violoett light.

Version: April 20, 1999.
  • Location of this page is http://www.lymenet.de/symptoms/cycles/TabInfl.htm
  • Send comments to Dr. Joachim Gruber.